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Concepts used when building the CRPS network in PathwayAssist (description in parenthesis). |
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| Node Type |
Node Name |
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| Complex |
Neuronal acetylcholine receptor[16, 98] |
| Functional Class |
NMDA receptor (N-methyl-D-aspartate receptor) [16, 98] |
| Protein |
CALCA (calcitonin/calcitonin-related polypeptide, alpha[46, 51]), IL1A (interleukin 1 alpha) [99], IL6 (interleukin 6) [13], NGFB (nerve growth factor, beta polypeptide), NGFG (nerve growth factor, gamma subunit) [79], NPY (neuropeptide Y[100]) [10], PTGS1 (prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)[101]) [10], TAC1 (tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin) [10], TACR1 (tachykinin receptor 1), TNF (tumor necrosis factor) 24, BDKRB2 (bradykinin receptor B2[45, 56, 57]) [102], PTGS2 (prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)) [20], NTRK1 (neurotrophic tyrosine kinase, receptor, type 1) 72, TRPV1 (transient receptor potential cation channel, subfamily V, member 1), Ngfa (nerve growth factor, alpha), BDK (Bradykinin), VIP (vasoactive intestinal peptide) |
| Small Molecule |
glutamate, DMSO (Dimethyl sulfoxide), PGE2 (Prostaglandin E2), magnesium, noradrenaline, capsaicin, glucocorticoid, mannitol, pentoxifylline, naproxen, bisphosphonate, verapamil, morphine, ketamine, amitriptyline, clonidine, carbamazepine, nortriptyline, lidocaine, GABA (gamma-aminobutyric acid), ketanserin, infliximab, gabapentin, amantadine, lioresal, benzodiazepine, Baclofen, N-acetyl-cystein |
Hettne et al. Journal of Biomedical Discovery and Collaboration 2007 2:2 doi:10.1186/1747-5333-2-2 |
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